Automated Sequence Control
PAPPL is proud to be the first pharmaceutical plant in Singapore that has automated the entire batch process of making our products. The site uses the state of the art DeltaV process control system, which programs all the unit operations and process steps to make up the master recipe for our products. Our process technicians are trained to use this system where they learn to integrate chemical reactions with the use of automated control systems.
Bin systems for solids handling
This is the first facility in Singapore to fully utilize bin to bin technology. This means that the raw materials are transferred into the process equipment by using intermediate bulk containers (IBCs). This takes into consideration the environment, health and safety aspects of handling materials, where any dust exposure or direct contact with products are eliminated and the work environment is extremely clean. The IBCs are used right from the start of the manufacturing process in the dispensary area, to the main production building, to the final pack-out where it is transferred into finished goods containers prior to shipment from the site.
Reactors for Chemical Reaction
The bulk of the process operations takes place in one of the many reactors available in the plant. The reactors are constructed either in Stainless Steel, Hastelloy or Glass Lined Carbon Steel. Solids in IBCs are charged to the reactors in a contained manner using docking stations on the floor above. This minimises operator and environmental exposure and maintains products integrity and quality.
The reactors on the plant are multi-functional. They can be used for a wide variety of operations including reactions, distillations, mixing, separations and crystallizations. The reactors can be interconnected to each other through the Process Transfer Station, which means the equipment can be set up in a manner which best suits the process. This allows Pfizer's Tuas facility the ability to manufacture a wide range of quality Pfizer products.
Hydrogenation Capacity
Hydrogenation is a chemical transformation process that involves the use of a catalyst and hydrogen in allowing a reaction to proceed. This technology gives the plant the flexibility to make products requiring this technology in a clean, fast and efficient manner. The plant is designed with stainless steel hydrogenators and is designed to minimize handling of raw materials. Each hydrogenator is fitted with its own self-discharging filter which allows for a controlled discharge of the spent catalyst. There is an allowance made in the plant layout to double the capacity of the hydrogenation unit.
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